We are glad to announce that GemPharmatech, in partnership with Qiwei Zhai’s research group at the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, has published a research paper in Nature Metabolism that revealed the main processes behind body fat rebound and obesity after dieting. 

Dietary restriction (DR), commonly known as dieting, immunodeficient mice is a method that relies on food limitation to manage body weight and reduce body fat. Many studies, however, have shown that dieters frequently experience a quick return to previous levels of  body fat.

This study used ten different dieting models and discovered that while different methods of food restriction effectively decreased body fat, none was capable of preventing a fast increase in body fat once dieting was stopped, followed by the formation of white lipid droplets in brown adipocytes and hepatic steatosis. This study revealed that rapid fat accumulation and obesity are caused by the rapid growth of Lactobacillus intestinalis and its metabolites during this process, as well as an increase in intestinal lipid absorption. This study also suggests that inhibiting intestinal lipid absorption by targeting Lactobacillus intestinalis with a high-protein diet or antibiotics may be an effective strategy to prevent body weight rebound and obesity after dieting.

GemPharmatech’s germ-free mice (GF) and newly developed gnotobiotic mice (GB) were used in this study to evaluate the mechanism of action of Lactobacillus intestinalis. Since GF mice can be colonized with foreign microorganisms and are not affected by individual variability in gut microbiota, they serve as a valuable tool for researching host-microbe interactions. The GB model was constructed using GF mice and eight strains of genetically well-defined microbes at specific quantities. This microbial cocktail represents the key phyla of the mouse gut microbiota, optimized for complexity and minimized for variation. 



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